Dr. Nebu George Thomas is a Professor in Periodontics and the Scientist in Charge of the Tissue Engineering and Regenerative Medicine Lab at Pushpagiri Research Centre. With over fourteen years of experience as a senior consultant in regenerative periodontal surgery and dental implantology, he specializes in designing scaffolds for tissue engineering applications and conducting preclinical analyses to assess the safety and regenerative potential of these scaffolds.
Our research focuses on developing novel biomaterials with enhanced tissue regeneration capabilities, aiming for cost-effective and sustainable solutions to chronic diseases and trauma. We are investigating the use of bio ceramics, natural and synthetic biomaterials known for its non-toxicity and superior tissue regeneration potential, as a means to improve treatment outcomes. Our innovative project involves creating a 3D printed nanocomposite scaffold that integrates osteoinductive, antibacterial properties, and biomimetic properties aimed towards periodontal, bone and soft tissue regeneration. This scaffold is designed to be economically viable and biocompatible, providing a promising option for regenerative surgical procedures. We plan to patent our findings and publish our work to share insights with the scientific and medical communities. Ultimately, our goal is to develop translatable therapies for tissue regeneration, minimizing side effects and promoting sustainable treatment regimens.
Thomas NG, Sanil GP, Rajmohan G, Prabhakaran JV, Panda AK. Fabrication and antimicrobial evaluation of drug loaded polylactide space filler intended for ridge preservation following tooth extraction. Journal of Indian Society of Periodontology. 2011 Jul 1;15(3):260-4. Impact Factor: 0.88
Rajmohan G, Jyothi PM, Nebu GT, Panda AK, Krishnan Nair CK. Preliminary biocompatibility assessment of polylactide membrane intended for wound healing. Pushpagiri Med J. 2011;13:22-4.
Omal PM, Jacob V, Prathap A, Thomas NG. Prevalence of oral, skin, and oral and skin lesions of lichen planus in patients visiting a dental school in southern India. Indian Journal of Dermatology. 2012 Mar 1;57(2):107-9. Impact Factor: 1.7
Thomas NG, Sanil GP, Gopi Mohan R, Prabhakaran JV, Thomas G, Panda AK. Biocompatibility and cytotoxic evaluation of drug-loaded biodegradable guided tissue regeneration membranes. Journal of Indian Society of Periodontology. 2012 Oct 1;16(4):498-503. Impact Factor: 0.88
George A, George SP, John S, George N, Joe S, Mathew R. Changes in inflammatory markers in bacterial-and nifedipine-induced gingival inflammation. Journal of international oral health: JIOH. 2015;7(Suppl 2):64. Impact Factor: 0.177
George VT, Mathew TA, George N, John S, Prakash SM, Vaseem MS. Efficacy of diode laser in the management of dentin hypersensitivity following periodontal surgery. Journal of International Oral Health. 2016 Jan 1;8(1):103-8. Impact Factor: 0.177
George VT, Mathew TA, George N, John S, Prakash SM, Vaseem MS. Efficacy of diode laser in the management of dentin hypersensitivity following periodontal surgery. Journal of International Oral Health. 2016 Jan 1;8(1):103-8. Impact Factor: 0.6
James N M, George V T, Thomas N G, Dalvi Y B, Varghese R, Ittycheria PG. (2020). Effect of Metformin on Alveolar Bone Loss in Type 2 Diabetic Rat Model with Experimental Periodontitis. IOSR Journal of Dental and Medical Sciences, 19(5), 58-67.
James NM, George TV, NG Thomas, John S, Ittycheria PG. Critical- Size defect models in Periodontal Regeneration. Kerala Dental Journal 2018; 41(4):206-212.
Augustine R, Dalvi YB, Dan P, George N, Helle D, Varghese R, Thomas S, Menu P, Sandhyarani N. Nanoceria can act as the cues for angiogenesis in tissue-engineering scaffolds: toward next-generation in situ tissue engineering. ACS Biomaterials Science & Engineering. 2018 Oct 22;4(12):4338-53. Impact Factor: 5.8
Thomas NG. Current and future prospective of marine based biomaterials in periodontal regeneration. IP International Journal of Periodontology and Implantology.2020 Dec 15; 5(4): 133
Pyas AM, Francis AM, George TV, Mathew AT, Thomas NG, etal. (2021) Bioactive Scaffolds for Alveolar Bone Regeneration. J Oral Health Dent, 5(1):376-389 Impact Factor: 1.5
Ittycheria PG, George AK, John S, George N. Evaluation of efficacy of autologous platelet-rich fibrin along with decalcified freeze-dried bone allograft in the management of mandibular grade-II Furcation defects–A clinical and radiographic study. IP International Journal of Periodontology and Implantology. 2023 Jan 22;4(1):11-7. Impact Factor: 0.59
G Meenu, Thomas NG, George T, Sherin P. Applications of tissue engineering in bone regeneration. International Journal of Advanced Dental Science and Research 2021 April; issue-2 pg-64
Raj SS, Thomas NG. Anti biofilm agents--Nature the cure. International Dental Journal of Students' Research. 2021 Jan 1;9(1).
Binsi PK, Ashraf PM, Thomas NG, Zynudheen AA. Thermal transition analysis of fish scale originated hydroxyapatite: AFM and electrochemical impedance spectroscopy as complimentary techniques. Journal of Thermal Analysis and Calorimetry. 2022 Mar;147(6):4027-45. Impact Factor: 4.4
Thomas NG, Manoharan A, Anbarasu A. Preclinical evaluation of sol-gel synthesized modulated 45s5-bioglass based biodegradable bone graft intended for alveolar bone regeneration. Journal of Hard Tissue Biology. 2021;30(3):303-8. Impact Factor: 0.4
Fijo? N, Abdelhamid HN, Pillai B, Hall SA, Thomas N, Mathew AP. 3D-printed monolithic biofilters based on a polylactic acid (PLA)–hydroxyapatite (HAp) composite for heavy metal removal from an aqueous medium. RSC advances. 2021;11(51):32408-18. Impact Factor: 3.9
Thomas NG, Anbarasu A. Cone-beam computed tomography-assisted evaluation of the bone regenerative potential of modulated sol–gel-synthesized 45S5 bioglass intended for alveolar bone regeneration. Journal of Pharmacy and Bioallied Sciences. 2022 Jul 1;14(Suppl 1): S123-6. Impact Factor: 2.849
Vellappally S, Naik S, Alsadon O, Al-Kheraif AA, Alayadi H, Alsiwat AJ, Kumar A, Hashem M, Varghese N, Thomas NG, Anil S. Perception of COVID-19 booster dose vaccine among healthcare workers in India and Saudi Arabia. International journal of environmental research and public health. 2022 Jul 22;19(15):8942. Impact Factor: 2.849
Sultan S, Thomas N, Varghese M, Dalvi Y, Joy S, Hall S, Mathew AP. The design of 3Dprinted polylactic acid–bioglass composite scaffold: a potential implant material for bone tissue engineering. Molecules. 2022 Oct 25;27(21):7214. Impact Factor: 4.927
Anil S, Ramadoss R, Thomas NG, George JM, Sweety VK. Dental pulp stem cells and banking of teeth as a lifesaving therapeutic vista. Biocell. 2023 Jan 1;47(1):71-80.Impact Factor: 1.18
Betsy J, George S, George N, Baiju KV, Sukumaran A, Joseph B, George SS. Perceptions of Indian healthcare practitioners regarding the 2022 outbreak of Monkeypox disease. Cureus. 2023 Feb 18;15(2). Impact Factor:1.2
Joy S, Thomas NG. Gymnemic acid?conjugatedgelatin scaffold for enhanced bone regeneration: A novel insight to tissue engineering. Biotechnology and Applied Biochemistry. 2023 Oct;70(5):1652-62. Impact Factor:2.43
Paul V, Mathew TA, Rasheed N, Thomas AS, George N. Photofunctionalization of Dental Implant Surfaces-A Histomorphometric Animal Study. Journal of Pharmacy and Bioallied Sciences. 2023 Jul 1;15(Suppl 1): S646-50. Impact Factor:1.26
Ittycheria PG, Veliyaveetil TG, George AK, John S, Thomas NG, Cherian SA. Effectiveness of Platelet-Rich Fibrin with Decalcified Freeze-Dried Bone Allograft Compared to Decalcified Freeze-Dried Bone Allograft Alone in Mandibular GradeII Furcation Defects: A Quasi-Experimental Study. Pesquisa Brasileiraem Odontopediatria e Clínica Integrada. 2023 Oct 20;23: e210126.
THOMAS NG, Dalvi YB, Fijol N, Shilpa J, Unni R, Binsi PK, Varghese MG, Reshmy R, Mathew A, Sukumaran A. Fish Scale Derived Hydroxyapatite Incorporated 3D Printed PLA Scaffold for Bone Tissue Engineering. New Journal of Chemistry. 2023. Impact Factor:3.3
Vellappally S, Naik S, Thomas RP, Alsadon O, Alayadi H, Hashem M, Alwadi MA, Thomas NG, Ali HM, Alsarani MM, Anil S. Knowledge of the monkeypox 2022 outbreak among dental hygienists and students in Saudi Arabia: A cross?sectional study. International Journal of Dental Hygiene. 2024 Feb 1. Impact Factor: 2.4
Manjubaashini N, Bargavi P, Thomas NG, Krishnan N, Balakumar S. Chitosan bioactive glass scaffolds for in vivo subcutaneous implantation, toxicity assessment, and diabetic wound healing upon animal model. International Journal of Biological Macromolecules. 2024 Jan 1;256:128291. Impact Factor:8.20
Chacko SK, Balakrishnan R, Karaikal N, Thomas NG. Ternary Fiber Mats of PVDFHFP/Cellulose/LiFe5O8 Nanoparticles with Enhanced Electric, Magnetoelectric, and Antibacterial Properties: A Promising Approach for Magnetic and Electric Field Responsive Antibacterial Coatings. ACS Applied Polymer Materials. 2024 Jan 11;6(2):1429-38. Impact Factor: 5
Shilpa J, Nebu GT. Functional regulation of hydroxyproline, ascorbic acid and lipid peroxidation during GABA chitosan nanoparticles mediated liver regeneration. Journal of Cellular Biotechnology. 2024 Jan 1;10(1):75-84
Thomas NG, Varghese MG, John PK, Raj SS, Jacob RS, Francis AM. Application of nanocomposites in dentistry. In Nanostructured Materials for Biomedical Applications 2024 Jan 1 (pp. 313-337). Elsevier.
Anil S, Thomas NG, Chalisserry EP, Dalvi YB, Ramadoss R, Vellappally S. Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth.J Vis Exp.2024 May 17(207). Impact Factor: 1.355
Fish Scale–Derived Hydroxyapatite for Alveolar Ridge Preservation. In Journal of Biotechnology and Applied Biochemistry DOI:10.1002,bab.2627. Impact Factor:3.01
Association between metabolic syndrome and salivary MMP-8,myeloperoxidase in periodontitis. In The journal Oral Diseases DOI:10.1111/odi.15014.Impact Factor: 3.8
Prathibha PM, Thomas NG, Dalvi YB, Varghese KG, Binsi PK, Zynudheen AA, Lekshmi M, Shilpa J, Sajith V, Sukumaran A. Fish scale-derived hydroxyapatite for alveolar ridge preservation. Biotechnol Appl Biochem. 2024 Jul 1. doi: 10.1002/bab.2627. Epub ahead of print. PMID: 38951991.
Kumar AS, Thomas NG, Dalvi YB, Letha SS, Sreelekshmi S, Rosemary MJ. Tailoring biodegradable elctrospun membrane for the potential treatment of periodontics: In vitro and in vivo evaluations. Materials Today Communications. 2024 Aug 1;40:109647.
Prathap S, Rajesh KS, Thomas NG, Venkateshan J, Prathap MS, Surya S. Domestic Chicken Eggshell-Derived Bone Substitute: Synthesis, Characterization and In Vitro Cell Viability. Journal of Pharmacy and Bioallied Sciences.2024 Aug 10-4103.
Mohammed R, Chacko SK, Balakrishnan R, Thomas NG, Binsi PK, Muhamed Ashraf P, Krishnan N, Anil S. Catechin as a functional additive in electrospun PCL/gelatin/nHA nanocomposite fibers for tissue engineering applications. Journal of Applied Polymer Science.: e56308. Impact factor: 3
George SS, Elenjickal MG, Naik S, Thomas NG, Vellappally S, Varghese N, Mathew A, Narayan V, Varughese RP, Sukumaran A. Oral health status and dental treatment needs in children with autism spectrum disorder. Heliyon. 2024 Sep 10. Impact factor: 3.7
Vellappally S, Naik S, Al Kheraif AA, Alayadi H, Alageel O, Alsarani MM, Ramadoss R, Thomas NG, Alateek M, Anil S. Fluoride Concentrations in Different Brands of Toothpaste Marketed in Saudi Arabia. International journal of dental hygiene.
Varghese MG, Thomas George V, Thomas NG, Pyas AM, Francis AM. Marine Based Biomaterials in Dental Regeneration. International Journal of Innovative Research in Medical Science (IJIRMS). 2020 Oct;5(10).
George VT, Thomas NG, John S, Ittycheria PG. The Scope of Stem Cells in Periodontal Regeneration: A Review. Journal of Dentistry, Oral Disorders & Therapy. 2015 June 5:70-94. Impact Factor: 1.2
Thomas NG, Thomas GV, Kavya S, Binsi PK, Aiswarya PM, Joy S, Nikhil MS, Jayachandran VP, Preetha G, George SS, Anil S. Marine biopolymers in tissue engineering applications. In Marine Biopolymers 2025 Jan 1 (pp. 491-527). Elsevier.
P.K. Binsi, U. Parvathy, A. Jeyakumari, Nebu George Thomas, A.A. Zynudheen,Chapter 23 - Marine biopolymers in cosmetics,, Marine Biopolymers,Elsevier, 2025, Pages 677-752, ISBN 9780443156069
Current Innovations in Medicine and Medical Science Vol. 9 – Book Store – B P International [Internet]. [cited 2023 Apr 22]. Available from:https://www.bookpi.org/bookstore/product/current-innovations-in-medicineandmedical-science-vol-9/.
“Toxicity of Natural Hydroxyapatite” accepted by Intech open access. Saumya John, Rakhi Manoharan, Kavya Suresh, Lekshmi Mini, Nibu Varghese, Sajith Vellapally and Nebu George Thomas
Nebu George Thomas, Shilpa Joy, Binci P K., Jayachandran V. P, Preetha G. Prasad, Sherin Jacob, Sherin Sara George, and Anil Sukumaran. Biomaterials from Sustainable Natural Sources for Tissue Engineering. 2023. Apple Academic Press.
Mridula Sreedharan, Jyothish Kumar J. S., Anjali G., Nebu George. Thomas, Shilpa Joy, Nandakumar Kalarikkal, and Sabu Thomas. Biomedical Applications of Magnetic Nanomaterials/Ferrites. 2023.Apple Academic Press.
NebuGeorgeThomas, Varghese N, Kalarikkal N, Thomas S, Sreedharan M, George SS, John S, Varghese MG, George VT. Toxicity Evaluation and Biocompatibility of Nanostructured Biomaterials. In Cytotoxicity 2023 Feb 2. IntechOpen.
Ruby Varghese, Yogesh Bharat Dalvi, P. Lochana, S. Achinthya, Bhagyashri Omprakash Somani, Preetha Karnaver, Nebu George Thomas, S. Rupesh, Nibu Varghese and Jayachandran V.P. Physiochemical and Biomedical Properties of Hydrogels: From Fundamentals to Applications.In Hydrogels and Nanogels Applications in Medicine Published: 05 January 2024. DOI: 10.5772/intechopen.1002027
John S, Manoharan R, Suresh K, Mini L, Varghese N, Vellapally S, Thomas NG. Toxicity of Natural Hydroxyapatite. In Novel Biomaterials for Tissue Engineering 2024 Jun 5. IntechOpen.
Varghese MG, Thomas A, Rupesh S, Sameer KM, Joseph D, Thomas NG. Fabrication Techniques for Scaffolds Applied in Regenerative Medicine. InNovel Biomaterials for Tissue Engineering 2024 Jun 5. IntechOpen
Shilpa Joy, Mridula Sreedharan Nikhil, Rojin Abraham, Sherin Sara George, Nebu George Thomas, and Anil Sukumaran Micro- and Nanoscale Technologies in Drug DeliveryA Contemporary Chemical Approach -Green Synthesis of Nanoparticles in Biomedicine Pub Date: Forthcoming November 2024CRC Press Hard ISBN: 9781774918388
Varghese MG, Thomas A, Rupesh S, Sameer KM, Joseph D, Thomas NG. Fabrication Techniques for Scaffolds Applied in Regenerative Medicine. InNovel Biomaterials for Tissue Engineering 2024 Jun 5. IntechOpen.
John S, Manoharan R, Suresh K, Mini L, Varghese N, Vellapally S, Thomas NG. Toxicity of Natural Hydroxyapatite. InNovel Biomaterials for Tissue Engineering 2024 Jun 5. IntechOpen.
Thomas NG, Joy S, Binci PK, Jayachandran VP, Prasad PG, Jacob S, George SS, Sukumaran A. Biomaterials from Sustainable Natural Sources for Tissue Engineering. InApplication of Engineering Principles and Practices in Biotechnology 2024 Sep 6 (pp. 43-86). Apple Academic Press.
Application Number: Indian government202441045392
Title: Antimicrobial Effect of Catechin-Doped Bioactive Glass Nanoparticles
Inventors: Dr. Sheena S Raj, Dr. A. Devadathan, Dr. Nebu George Thomas, Dr. Emil George
Patent Number: 455693
Title: Process for the Fabrication of Multi-Layered Porcine Cholecystic Extracellular Matrix (CECM) For Tissue Engineering Applications.
Inventors: Dr. Nebu George Thomas, Dr. Yogesh Bharath Dalvi, Dr. Thapasimuthu Vijayamma Anilkumar, Mr. Pratheesh Kanakarajan Vijayakumari