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The Medical Biotechnology and Computational Drug Designing Laboratory is dedicated to understanding and addressing the causes of antimicrobial resistance through advanced techniques in genomics, proteomics, systems biology, and structural bioinformatics. Our research focuses on clinically significant nosocomial bacterial pathogens and developing sustainable therapeutic regimens by combining active phytocompounds from medicinal plants with effective antibiotics. All our experiments adhere to guidelines set by the World Health Organization (WHO) and The Indian Council of Medical Research (ICMR), following CLSI breakpoints and EUCAST standards.
We also emphasize isolating and characterizing novel probiotics with high nutritional value and enhanced immune-modulatory potential. Our lab has a proven track record of screening and characterizing novel probiotic strains from student projects, which are successfully deposited in the NCBI database. Equipped with cutting-edge workstations, we conduct extensive computational research to design novel antimicrobial peptides and lead molecules through computer-aided drug design (CADD). Our lab has successfully modeled several protein structures through computational experimentation and deposited them in the Protein Model Database for public use.
Our work also extends to bioremediation strategies for treating sewage and wastewater, as well as phyto-rhizoremediation techniques. The lab is extensively equipped with instruments for in-silico and in-vitro experiments, including advanced workstations for genomics and computational drug design, orbital shaking incubators, autoclaves, rotary shakers, water baths, precision weighing balances, heating mantles, heating plates with magnetic stirrers, Gel-doc instruments, and basic extraction and chromatographic setups for clinical, food, and environmental microbiological experiments.
The lab has received institutional funding for research and has a strong track record of publishing papers in international peer-reviewed journals. We are actively involved in guiding students for their dissertation projects and hands-on training activities. Dr. Aniket conducts several hands-on training sessions to help students cope with advanced and AI-based technologies.
Naha, A., Nath, D.C. and Nath, S., 2020. Impact of pesticides on the growth of Coriandrum sativum. International Journal of Plant Physiology and Biochemistry, 12(1), pp.17-25.
Miryala, S.K., Basu, S., Naha, A., Debroy, R., Ramaiah, S., Anbarasu, A. and Natarajan, S., 2022. Datasets comprising the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of Mycobacterium tuberculosis protein-targets. Data in brief, 42, p.108146.
Naha, A., Miryala, S.K., Debroy, R., Ramaiah, S. and Anbarasu, A., 2020. Elucidating the multi-drug resistance mechanism of Enterococcus faecalis V583: a gene interaction network analysis. Gene, 748, p.144704.
Naha, A. and Ramaiah, S., 2022. Structural chemistry and molecular-level interactome reveals histidine kinase EvgS to subvert both antimicrobial resistance and virulence in Shigella flexneri 2a str. 301. 3 Biotech, 12(10), p.258.
Naha, A., Vijayakumar, S., Lal, B., Shankar, B.A., Chandran, S., Ramaiah, S., Veeraraghavan, B. and Anbarasu, A., 2021. Genome sequencing and molecular characterisation of XDR Acinetobacter baumannii reveal complexities in resistance: Novel combination of sulbactam–durlobactam holds promise for therapeutic intervention. Journal of Cellular Biochemistry, 122(12), pp.1946-1957
Basu, S., Naha, A., Veeraraghavan, B., Ramaiah, S. and Anbarasu, A., 2022. In silico structure evaluation of BAG3 and elucidating its association with bacterial infections through protein–protein and host?pathogen interaction analysis. Journal of Cellular Biochemistry, 123(1), pp.115-127.
Debroy, R., Miryala, S.K., Naha, A., Anbarasu, A. and Ramaiah, S., 2020. Gene interaction network studies to decipher the multi-drug resistance mechanism in Salmonella enterica serovar Typhi CT18 reveal potential drug targets. Microbial pathogenesis, 142, p.104096.
Naha, A. and Ramaiah, S., 2024. Novel antimicrobial peptide SAAP mutant as a better adjuvant to sulbactam-based treatments against clinical strains of XDR Acinetobacter baumannii. Probiotics and Antimicrobial Proteins, 16(2), pp.459-473.
https://pubmed.ncbi.nlm.nih.gov/36971982/Naha, A., Banerjee, S., Debroy, R., Basu, S., Ashok, G., Priyamvada, P., Kumar, H., Preethi, A.R., Singh, H., Anbarasu, A. and Ramaiah, S., 2022. Network metrics, structural dynamics and density functional theory calculations identified a novel Ursodeoxycholic Acid derivative against therapeutic target Parkin for Parkinson's disease. Computational and Structural Biotechnology Journal, 20, pp.4271-4287.
https://www.sciencedirect.com/science/article/pii/S2001037022003518Miryala, S.K., Basu, S., Naha, A., Debroy, R., Ramaiah, S., Anbarasu, A. and Natarajan, S., 2021. Identification of bioactive natural compounds as efficient inhibitors against Mycobacterium tuberculosis protein-targets: a molecular docking and molecular dynamics simulation study. Journal of Molecular Liquids, 341, p.117340.
https://www.sciencedirect.com/science/article/abs/pii/S016773222102064XUsharani, N., Naha, A., Anbarasu, A., Ramaiah, S., Kanth, S.V. and Natarajan, S., 2023. Green synthesis and characterization of water soluble nanocarnosine: A prospective drug delivery system. Applied Materials Today, 32, p.101812.
https://www.sciencedirect.com/science/article/abs/pii/S2352940723000823Bhowmik, D., Chetri, S., Enerijiofi, K.E., Naha, A., Kanungo, T.D., Shah, M.P. and Nath, S., 2023. Multitudinous approaches, challenges and opportunities of bioelectrochemical systems in conversion of waste to energy from wastewater treatment plants. Cleaner and Circular Bioeconomy, 4, p.100040.
Nath, S., Astapati, A.D., Naha, A., Sharma, I. and Shah, M.P., 2024. Algal-based membrane bioreactors for effective removal of hazardous and toxic contaminants: A comprehensive review. Current Research in Biotechnology, p.100201.
Naha, A., Debroy, R., Sharma, D., Shah, M.P. and Nath, S., 2023. Microbial fuel cell: A state-of-the-art and revolutionizing technology for efficient energy recovery. Cleaner and Circular Bioeconomy, 5, p.100050.
Naha, A., Antony, S., Nath, S., Sharma, D., Mishra, A., Biju, D.T., Madhavan, A., Binod, P., Varjani, S. and Sindhu, R., 2023. A hypothetical model of multi-layered cost-effective wastewater treatment plant integrating microbial fuel cell and nanofiltration technology: a comprehensive review on wastewater treatment and sustainable remediation. Environmental Pollution, 323, p.121274.
https://www.sciencedirect.com/science/article/abs/pii/S0269749123002762Nath, S., Naha, A. and Chowdhury, M.H., Mapping the molecular basis and preventive strategies of Covid-19: A review towards evoking public awareness In : Biological Sciences: Impacts on Modern Civilization, Current and Future Challenges by Anupam Guha © New Delhi Publishers, New Delhi: 2020, 103-107, ISBN: 978-81-947417-9-4
https://prc.pushpagiri.in/2022/12/05/biotechnology-bioinformatics/Mishra, A., Naha, A., Soundharya H., Nath, S., Varghese, N. and Soumya, RS., Designing Novel Serine Protease Inhibitors against Potential Biomarkers Specific to Lung Adenocarcinoma through Systems Biology and Structural Bioinformatics Approaches; Handbook of Proteases in Cancer; Taylor and Francis, CRC Press
Bioelectricity Production with Triple Anodic Chamber Microbial Fuel Cells in static and Dynamic Environments – Two Days National Seminar on Recent Development in Science and Technology organised by Department of Chemistry, Karimganj College, Karimganj, Assam
