In-Vivo Facilities :

Animal House facility for performing pre-clinical analysis of scaffolds as per ISO guidelines (ISO 10993-1:2009, ISO 10993-3:2014, ISO 10993-4:2017, ISO 10993-5:2009, ISO 10993-6:2016, ISO 10993-10:2010, ISO 10993-11:2017) for tissue engineering scaffolds used in regenerative medicine. The different experiments carried out are as follows:

• Genotoxicity
• Mammalian test systems
• Nonmammalian test systems
• Intracutaneous Reactivity
• Skin Sensitization Assay
• Acute Systemic Toxicity
• Hemocompatibility
• Complement Activation
• Thrombogenicity
• Pyrogenicity
• Carcinogenicity
• Implantation
• Performance and Efficacy Evaluation
• Osseointegration and Critical-Size Defects
• Long-Bone Pressure Fitted Transcortical Placement
• Trephined bone core repair
• Mandibular Osteotomy Defect Repair
• Osteomyelitis and Antimicrobial Treatments
• Osteoinduction Models
• Dental Implants and Guided Bone Regeneration
• Teeth extraction procedure
• Bone graft implantation procedure
• Dental implant placement
• Imaging
• Live computed tomography (Cone beam CT-scan)
• Magnetic resonance imaging (MRI)
• Micro-computed tomography (micro-CT)
• Necropsy and Macroscopic Grading (Gross Pathology)
• Histology
• Sample preparation
• Nondecalcified (plastic) histology
• Decalcified histology
• Histopathology
• Local effects on hard tissue
• Local effects on soft (cartilage) tissues
• Effects on major organs
• Abnormal macroscopic findings and gross lesions
• Histology Imaging
• Histomorphometry

LAB FACILITIES :

•  Isoflurane anaesthesia chamber
•  Euthanasia chamber
•  Housing facilities for laboratory animals