Biochemistry Lab

Nanoscience, Metabolic diseases, Mitochondrial biology, Cardiovascular biology

• Soumya RS, Raghu KG. Recent advances on nanoparticle-based therapies for cardiovascular diseases. J Cardiol. 2023 Jan;81(1):10-18. doi:10.1016/j.jjcc.2022.02.009. Epub 2022 Feb 21. PMID: 35210166.
• Soumya RS, Binu Raj K, and Annie Abraham. Passiflora edulis (var. Flavicarpa) juice supplementation mitigates isoproterenol-induced myocardial infarction in rats. Plant Foods for Human Nutrition. (Dordrecht, Netherlands). 2021, 76, 189-195.
• Soumya RS, Unni TG, Raghu KG. Impact of COVID-19 on the cardiovascular system: A review of available reports. Cardiovascular Drugs and Therapy. 2021, 35, 411-425.
• Soumya RS, Sherin S, Raghu KG, Abraham A. Allicin functionalized locust bean gum nanoparticles for improved therapeutic efficacy: An in silico, in vitro and in vivo approach. International Journal of Biological Macromolecules. 2018, 109,740-747.
• Soumya RS, Prathapan A, Raj PS, Vineetha VP, Raghu KG. Selenium-incorporated guar gum nanoparticles safeguard mitochondrial bioenergetics during ischemia-reperfusion injury in H9c2 cardiac cells. International Journal of Biological Macromolecules. 2018, 107(Pt A), 254-260.
• Savitha DP, Anjali KG, Divya KM, SoumyaRS, Raghu KG,.Mohanan P V. Isatin derived novel Schiff bases: An efficient pharmacophore for versatile biological applications. Journal of Molecular Structure.2023, 1271, 5, 134121.
• Sherin S, Sheeja S, Sudha Devi R, Balachandran S, Soumya RS, Abraham A. In vitro and in vivo pharmacokinetics and toxicity evaluation of curcumin incorporated titanium dioxide nanoparticles for biomedical applications. Chemico Biological Interaction. 2017, 275, 35-46.
• Soumya RS, Reshmi R, Jomon S, Antu KA, Riya MP, Raghu KG. Synthesis, characterization and evaluation of the antioxidant potential of vanadium-encapsulated guar gum nanoparticles. Food & Function. 2014, 5, 535-544.
• Soumya RS, Vineetha VP, Raj PS, Raghu KG. Beneficial properties of selenium incorporated guar gum nanoparticles against ischemia/reperfusion in cardiomyoblasts (H9c2). Metallomics. 2014, 6, 2134-2147.
• Soumya RS, Vineetha VP, Reshma PL, Raghu KG. Preparation and characterization of selenium-incorporated guar gum nanoparticle and its interaction with H9c2 cells. PloS one. 2013, 8 (9), e74411
• Soumya RS, Ghosh S, Abraham ET. Preparation and characterization of guar gum nanoparticles. International Journal of Biological Macromolecules. 2010, 46, 267- 269.
• Soumya RS, Abraham ET. Isolation of β-mannanase from Cocos nucifera Linn haustorium and its application in the depolymerization of β-(1, 4)-linked d-mannans. International Journal of Food Sciences and Nutrition. 2010, 61, 272-281.
• Sankar V, SalinRaj P, Athira R, Soumya RS, Raghu KG. Cerium nanoparticles synthesized using aqueous extract of Centella Asiatica: characterization, determination of free radical scavenging activity and evaluation of efficacy against cardiomyoblast hypertrophy. RSC Advances. 2015, 5, 21074-21083.
• Vineetha VP, Soumya RS, Raghu KG. Phloretin ameliorates arsenic trioxide-induced mitochondrial dysfunction in H9c2 cardiomyoblasts mediated via alterations in membrane permeability and ETC complexes. European Journal of Pharmacology. 2015, 754, 162-172 15. Vineetha VP, Girija S, Soumya RS, Raghu KG. Polyphenol-rich apple (Malus domestica L.) peel extract attenuates arsenic trioxide-induced cardiotoxicity in H9c2 cells via its antioxidant activity. Food & Function. 2014, 5, 502-511
• Vineetha VP, Prathapan A, Soumya RS, Raghu KG. Arsenic trioxide toxicity in H9c2 myoblasts—damage to cell organelles and possible amelioration with Boerhavia diffusa. Cardiovascular Toxicology. 2013, 13, 123-137.
• Book Chapters :
• Book Title: Micro and Nano Engineered Gum-Based Biomaterials for Drug Delivery and Biomedical Application; Chapter: Locust bean gum based micro and nanomaterials for biomedical applications, RS Soumya a , KG Raghu a & Annie Abraham b *ISBN eBook ISBN: 9780323909877,Paperback ISBN: 9780323909860 Elsevier.
• Book Title: “Polysaccharide-based biomaterials: Delivery of Therapeutics & Biomedical Applications”, Chapter: Locust Bean Gum-A Potential Drug Delivery Carrier, RS Soumya a , KG Raghu a & Annie Abraham b *, The Royal Society of Chemistry (RSC), UK.ISBN:9781839164989.

We at the biochemistry laboratory @ Pushpagiri research centre are providing diagnostic facility for inborn errors of metabolism.
1. HPLC diagnosis for all aminoaciduria
We shall provide academic support towards management disorders including the latest, state-of-the-art literature support.
2. High-performance liquid chromatography (HPLC),
3. Chemiluminescence immunoassay (CLIA),
4. Real-Time (RT-PCR),
5. Enzyme-linked immunoassay (ELISA),
6. Western Blotting,
7. Spectrophotometer.

Dr Soumya R.S, Scientist, Pushpagiri Research Centre, has been approved as a research guide in the subject area of Medical Biochemistry by Kerala University of Health Sciences.(U.O. No 262l2023/dean/KUHS dated 12/04/2023)